What is New with CAR T-cell Therapy?
SELF STUDY / ENDURING - ESTIMATED TIME TO COMPLETE ACTIVITY: 60 Minutes
More than 130 centers in the US now have CAR-T programs and 1300 clinical trials in CAR-T are listed in the NCI database. In this webcast, expert faculty will review how CAR-T therapies work and the commercially available therapies specific to patients with hematologic and non-hematologic malignancies. The unique adverse events associated with CAR-T will be discussed and faculty will share strategies to reduce morbidity and mortality due to cytokine release syndrome (CRS) and neurotoxicity (NT). Faculty will use a case study to help advanced practice providers understand how to assess and manage adverse events in a patient receiving CAR-T therapy.
This CME initiative was designed for oncologists, surgeons, radiation oncologists, NPs, PAs, pharmacists, nurses, and other healthcare professionals involved in the treatment of patients with cancer.
1. Describe the mechanism of action and intended targets of chimeric antigen receptor (CAR) T-cell
2. Review the approved indications for commercially available CAR T-cell therapies used in patients with hematologic and non-hematologic malignancies
3. Classify the patient monitoring recommendations post-treatment to aid APPs in identifying acute and long-term adverse reactions associated with CAR T-cell therapy
4. Identify strategies for monitoring and managing cytokine release syndrome (CRS) and neurotoxicity (NT) to reduce morbidity and mortality
Jennie Goble PA-C
Jennie Goble is a Physician Assistant in the Division of Hematology at the Mayo Clinic in Rochester, MN. She is an Instructor in the College of Medicine and has a Master’s degree in Physician Assistant Studies.
Jennie has been a Physician Assistant in Hematology for almost 9 years and has practiced in both the inpatient and hospital outpatient settings. She is Silver Quality certified and frequently participates in projects and in education and mentoring of new providers. Clinical interests include acute leukemia and high-grade lymphoma Her passions are high-quality patient care, NPPA education, and quality improvement.
In accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education, Horizon CME (HCME) ensures that continuing education activities are balanced, independent, objective, and scientifically rigorous.
All persons in a position to influence the content of an accredited continuing education activity provided by Horizon CME are required to disclose to HCME any relevant financial relationships with ineligible companies within the past 24 months. All reported relevant financial relationships have been mitigated by Horizon CME.
Jennie M. Goble discloses no relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on, patients during the past 24 months.
- 1.00 AMA PRA Category 1 Credit™Horizon CME designates this Enduring activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
- 1.00 ANCCThis activity has been planned and implemented in accordance with the accreditation requirements and policies of the American Nurses Credentialing Center’s Commission on Accreditation through the joint providership of the Nurse Practitioner Healthcare Foundation and Horizon CME. The Nurse Practitioner Healthcare Foundation is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation. NPHF is awarding the contact hours and is responsible for adherence to the ANCC criteria. This course is approved by the Nurse Practitioner Healthcare Foundation, California Board of Registered Nursing, CEP# 16441. Upon completion, NPs and RNs will be awarded up to 1.00 credit.
There are no fees for participating and receiving CME credit for this enduring activity. To receive CME credit participants must:
- Read the CME/CE information and faculty disclosures.
- Participate in the online activity.
- Complete the post-test and score a minimum of 70%
- Submit the evaluation form.
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DISCLOSURE OF UNLABELED USE:
Horizon CME requires that faculty participating in any CME activity disclose to the audience when discussing any unlabeled or investigational use of any commercial product or device not yet approved for use in the United States.
This activity is designed for educational purposes. Participants have a responsibility to utilize this information to enhance their professional development to improve patient outcomes. Conclusions drawn by the participants should be derived from careful consideration of all available scientific information. The participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision-making before applying any information, whether provided here or by others, for any professional use.