Navigating the Complexities of Cellular Therapy: Identifying Risks and Interventions to Minimize Toxicity

SELF STUDY / ENDURING - ESTIMATED TIME TO COMPLETE ACTIVITY: 45 Minutes

Overview

This program offers an in-depth exploration of the complexities of cellular therapy, focusing on risk identification and toxicity management. Participants will delve into key risk factors for febrile neutropenia and sepsis, as well as the clinical presentation of oncologic emergencies such as CRS, ICANS, and HLH/MAS. Through case-based scenarios, attendees will gain practical insights into the effective management of these conditions, guided by ASTCT recommendations, to enhance patient care in the context of advanced cellular therapies.

Target Audience

This CME initiative was designed for oncologists, surgeons, radiation oncologists, NPs, PAs, pharmacists, nurses, and other healthcare professionals involved in the treatment of patients with cancer.

Learning Objectives

  1. Identify risk factors for febrile neutropenia and sepsis in patients undergoing cellular therapy to enhance early recognition and effective symptom management.
  2. Recognize the clinical presentation of oncologic emergencies associated with cellular therapies including, cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS) and immune effector cell-associated hemophagocytic lymphocytosis (HLH) / Macrophage Activation Syndrome (MAS) to facilitate prompt intervention and minimize patient morbidity.
  3. Discuss the American Society for Transplantation and Cellular Therapy (ASTCT) recommendations that advanced practice providers (APPs) can use to guide the effective management of oncologic emergencies associated with cellular therapy
     

 

Course summary
Available credit: 
  • 0.75 AMA PRA Category 1 Credit™

    This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME). Horizon CME is accredited by the ACCME to provide continuing medical education for physicians.

    Horizon CME designates this Enduring activity for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Course opens: 
09/05/2025
Course expires: 
09/05/2026
Cost:
$0.00
Rating: 
0

Faculty

Meredith Durbin, ARNP

Advanced Registered Nurse Practitioner
Fred Hutchinson Cancer Center
Seattle, WA

Meredith is a nurse practitioner at Fred Hutch caring for patients receiving CAR-T therapy and cellular therapy products on clinical trials. She enjoys following and partnering with patients through the cellular therapy process from start to completion. She works with a fabulous team, and cannot imagine getting their patients to the other side of treatment without their collaboration. In her free time, Meredith enjoys playing with  her toddler, running, and playing piano. 

Disclosures:

In accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education, Horizon CME (HCME) ensures that continuing education activities are balanced, independent, objective, and scientifically rigorous. 

All persons in a position to influence the content of an accredited continuing education activity provided by Horizon CME are required to disclose to HCME any relevant financial relationships with ineligible companies within the past 24 months. All reported relevant financial relationships have been mitigated by Horizon CME.

Meredith Durbin, ARNP discloses no relevant financial relationships with any entity producing, marketing, re-selling, or distributing healthcare goods or services consumed by, or used on, patients during the past 24 months.

Available Credit

  • 0.75 AMA PRA Category 1 Credit™

    This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME). Horizon CME is accredited by the ACCME to provide continuing medical education for physicians.

    Horizon CME designates this Enduring activity for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Price

Cost:
$0.00
Please login or register to take this course.

There are no fees for participating and receiving CME credit for this enduring activity. To receive CME credit participants must:

  1. Read the CME/CE information and faculty disclosures.
  2. Participate in the online activity.
  3. Complete the post-test
  4. Submit the evaluation form

DISCLAIMER:

This activity is designed for educational purposes. Participants have a responsibility to utilize this information to enhance their professional development to improve patient outcomes. Conclusions drawn by the participants should be derived from careful consideration of all available scientific information. The participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision-making before applying any information, whether provided here or by others, for any professional use.

Required Hardware/software

Access to the internet is required.

Supported Browsers:

Internet Explorer 8.0+ for Windows 2003, Vista, XP, Windows 7, Windows 8.1 and above

Google Chrome 28.0+ for Windows, Mac OS, or Linux

Mozilla Firefox 23.0+ for Windows, Mac OS, or Linux

Safari 6.0+ for Mac OSX 10.7 and above

 

Supported Phones & Tablets:

 Android 4.0.3 and above

iPhone/iPad with iOS 6.1 or above