Updates in Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer Therapy: MARIPOSA Trial

May 22, 2025

- This oncology pharmacy journal club program will be a virtual (online) event. -

Overview

This virtual oncology pharmacy journal club provides an interactive, accredited platform for pharmacists to critically evaluate emerging literature, discuss real-world clinical challenges, and apply evidence-based strategies to patient care. Designed specifically for oncology pharmacists, the program fosters ongoing professional development, enhances therapeutic decision-making, and supports the evolving role of pharmacists within the cancer care team.

This session will review the MARIPOSA trial evaluating amivantamab and lazertinib versus osimertinib in the first-line therapeutic setting for metastatic EGFR-mutated non-small cell lung cancer (NSCLC). We will briefly discuss the historical treatment of EGFR-mutated NSCLC, the findings of this trial, and how these findings impact the current clinical practice.

Identified Gap(s)
Oncology pharmacists lack regular, structured opportunities to engage with emerging literature and apply new evidence to clinical practice. The rapid pace of drug development, evolving treatment guidelines, and increasing complexity of oncology care demand ongoing education that is interactive and peer-driven. The absence of oncology-specific journal clubs limits pharmacists’ ability to stay current, critically evaluate research, and contribute fully to multidisciplinary care—ultimately impacting patient outcomes.

Description of Current State
Oncology pharmacists are increasingly stepping into high-value, patient-focused roles due to the growing complexity of cancer care and shortages of oncologists and nurses. With over 50 new cancer drugs approved in 2024 alone, the need for pharmacists to stay current with treatment advances is critical.1 However, educational gaps persist, as pharmacists often lack access to oncology-focused continuing education. As drug experts on the care team, they must be equipped to manage complex therapies and fill care gaps—particularly in areas like pregnancy-associated cancer and supportive care.

Description of desired/achievable state
Oncology pharmacists will have access to a virtual, accredited journal club designed to support continuous learning and clinical application of emerging evidence. This interactive platform will foster peer-to-peer discussion, enhance critical literature appraisal skills, and empower pharmacists to deliver evidence-based care in complex scenarios, ultimately strengthening their role within the oncology care team.
 

Upon completion of this journal club, you will:

  1. Review recent primary literature with clinical implications in the treatment of advanced EGFR-mutated non-small cell lung cancer (NSCLC)            
  2. Analyze the MARIPOSA trial, its significance to the oncology practice, and therapeutic impact in NSCLC

Target Audience

This activity is intended for oncology pharmacists, pharmacy techs, and pharmacy residents who are involved in the treatment of cancer patients.

Presented By

                                                        

Course summary
Available credit: 
  • 0.50 ACPE Pharmacy
    The Washington State Pharmacy Association is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. This conference is approved for up to 0.50 credit by the Washington State Pharmacy Association.

    This activity is approved for up to 0.50 credit by the Washington State Pharmacy Association. ACPE#: 0130-9999-21--L01-P | Activity Type: Live| Start/End date: Thu, 05/22/2025 - 11:55am-Thu, 05/22/2025 - 12:35pm The Washington State Pharmacy Association (WSPA) is accredited by the Accreditation Council for Pharmacy Education as a Provider of continuing pharmacy education. NOTE FOR PHARMACISTS: It is the responsibility of the pharmacist or pharmacy technician to provide the correct information [NABP eProfile ID and DOB (in MMDD format)] within the evaluation, in order to receive credit for participating in this CPE activity. Following the activity’s end date, there is a maximum of 60 days allowed to upload the CPE information to the CPE Monitor. WSPA will upload the CPE information to the CPE monitor 50 days after the activity - please check your CPE Monitor at this time to ensure the CPE is uploaded in your profile. If you encounter any CPE problems, please contact WSPA at 425- 228-7171
Course opens: 
04/15/2025
Course expires: 
06/23/2025
Event starts: 
05/22/2025 - 11:55am PDT
Event ends: 
05/22/2025 - 12:35pm PDT
Cost:
$0.00
Add to calendar: 
Rating: 
0

Please note: times are subject to change. Please check the syllabus for the most current version of the agenda upon arriving at the summit.

All Times Listed are for the Eastern Standard Time Zone

Thursday, May 22, 2025

2:55pmWelcome and Introduction
» Kyle Zacholski, PharmD -  BCOP PGY2 Oncology Pharmacy Resident - Virginia Commonwealth University Health System - Richmond, VA
3:00pmUpdates in Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer Therapy: MARIPOSA Trial
» Kelsey Oberholtzer, PharmD - Clinical Pharmacy Specialist, Hematology & Oncology - Virginia Commonwealth University Health System- Richmond, VA
3:30pmClosing Comments
» Kyle Zacholski, PharmD, BCOP - BCOP PGY2 Oncology Pharmacy Resident - Virginia Commonwealth University Health System - Richmond, VA
Online Livecast
United States

Faculty

Kyle Zachoiski, PharmD, BCOP (Moderator)

Clinical Pharmacy Specialist,
Hematology & Oncology 
Virginia Commonwealth University Health System
Richmond, VA

Dr. Kyle Zacholski is a board-certified oncology pharmacist at VCU Health and clinical assistant professor at VCU School of Pharmacy in Richmond, VA. At VCU Health, he serves as the program director for the PGY2 Oncology Pharmacy Residency program and specializes in malignant hematology with over 5 years of clinical practice experience. His research interests include optimizing treatment and supportive care for patients with acute leukemia and bone marrow failure syndromes. Dr. Zacholski also currently serves as a pharmacy committee member for the Alliance for Clinical Trials in Oncology cooperative group.

Kelsey Oberholtzer, PharmD (Speaker)

PGY2 Oncology Pharmacy Resident
Virginia Commonwealth University Health System
Richmond, VA

Kelsey Oberholtzer is a current PGY2 Oncology Pharmacy resident at VCU Health System in Richmond, VA. She received her undergraduate degree in Biochemistry from Virginia Tech followed by her PharmD from VCU School of Pharmacy. Kelsey completed her PGY1 Acute Care Pharmacy training at VCU Health prior to starting her PGY2. Kelsey's clinical interests include malignant hematology, bone marrow transplant, and pediatric oncology. 

Program Planner

Shawn Griffin

Oncology Pharmacist/Assistant Clinical Professor
University of California, Irvine 
Irvine, California

Shawn Griffin is a Board Certified Oncology Pharmacist and Health Sciences Assistant Clinical Professor in the Department of Clinical Pharmacy Practice at the University of California, Irvine (UCI) School of Pharmacy & Pharmaceutical Sciences. He practices within the Hematopoietic Stem Cell Transplantation and Cellular Therapy Program at the Chao Family Comprehensive Cancer Center. Prior to joining UCI, Griffin worked as a Hematology/Stem Cell Transplant pharmacist at Indiana University Health for five years. He received PharmD from the UNC Eshelman School of Pharmacy and completed a PGY1 Pharmacy and PGY2 Oncology Pharmacy Residency at the University of Florida Health Shands Hospital.

Disclosures

Horizon CME requires all planners, faculty, and other contributors to disclose any financial relationships with an ACCME defined ineligible company within the past 24 months and Horizon CME has resolved any conflicts prior to this educational activity.
Planners

*Horizon CME has mitigated and resolved all relevant financial relationships

Kyle Zachoiski, PharmD, BCOP - Kyle Zacholski, PharmD, BCOP discloses Advisory Board with Verastem, during the past 24 months.

Those others involved in the planning of this activity disclosed no relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on, patients.
Other Contributors

Other Contributors

All other non-faculty contributors and others involved in the planning, development and editing/review of the content disclosed no relevant financial relationships with any entity producing, marketing, re-selling or distributing health care goods or services consumed by or used on patients.

Available Credit

  • 0.50 ACPE Pharmacy
    The Washington State Pharmacy Association is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. This conference is approved for up to 0.50 credit by the Washington State Pharmacy Association.

    This activity is approved for up to 0.50 credit by the Washington State Pharmacy Association. ACPE#: 0130-9999-21--L01-P | Activity Type: Live| Start/End date: Thu, 05/22/2025 - 11:55am-Thu, 05/22/2025 - 12:35pm The Washington State Pharmacy Association (WSPA) is accredited by the Accreditation Council for Pharmacy Education as a Provider of continuing pharmacy education. NOTE FOR PHARMACISTS: It is the responsibility of the pharmacist or pharmacy technician to provide the correct information [NABP eProfile ID and DOB (in MMDD format)] within the evaluation, in order to receive credit for participating in this CPE activity. Following the activity’s end date, there is a maximum of 60 days allowed to upload the CPE information to the CPE Monitor. WSPA will upload the CPE information to the CPE monitor 50 days after the activity - please check your CPE Monitor at this time to ensure the CPE is uploaded in your profile. If you encounter any CPE problems, please contact WSPA at 425- 228-7171

Price

Cost:
$0.00
Please login or register to take this course.

Required Hardware/software

Access to the internet is required.

Supported Browsers:

Internet Explorer 8.0+ for Windows 2003, Vista, XP, Windows 7, Windows 8.1 and above

Google Chrome 28.0+ for Windows, Mac OS, or Linux

Mozilla Firefox 23.0+ for Windows, Mac OS, or Linux

Safari 6.0+ for Mac OSX 10.7 and above


Supported Phones & Tablets:

Android 4.0.3 and above

iPhone/iPad with iOS 6.1 or above

How to obtain credit for attendance (eligibility requirement and process for obtaining certificate)
To receive documentation of credit, participants must:

  1. Login to the educational portal

  2. Attend the educational activity

  3. Complete the online evaluation form. The last day to access the evaluation is June 23, 2025 at 11:59pm PST* 

  4. Attest to the number of hours in attendance in order to generate your certificate 

*Requests from learners to claim credit after the evaluation closes will not be granted